Six close friends meet each week for a game night involving board games, charades and pop culture trivia quizzes. Being the most competitive of the bunch, Max and his wife Annie, who seem to be a perfect match in every way, usually win every time. However, their marriage is on rocky ground as Annie fears that Max doesn't want to have children. When Max's shady brother Brooks reappears after a long mysterious absence and suggests that they have their next gathering at his place, no one expects that their weekly game night is about to go to the next level as Brooks organizes a full blown murder mystery party complete with actors as criminals and cops for them. However, when Brooks is violently kidnapped in front of everyone, it turns out that the game is all too real. Now, Max, Annie, their womanizing dimwitted friend Ryan, his domineering Irish date Sarah, and their childhood friends Michelle and her husband Kevin, who's obsessed with finding out with which mysterious celebrity Michelle cheated him on once, must join forces and their wits to rescue Brooks from two dangerous rival criminals who seemingly want his head. Unfortunately, they'll also need help from their creepy introverted next door neighbor Gary, a grieving divorcee cop who desperately wants to be their friend.